Van de Ven Double Ends The Toffees' Run at New Home Ground
The Dutch defender became the initial backline player to score twice in a Premier League game for Tottenham since Jan Vertonghen in March 2013.
At a glance
The Spurs defender nods into the net twice in opening period
Everton's defender has goal disallowed after VAR review
Pape Matar Sarr scores third in dying moments
This loss is the Merseyside club's initial at their new ground
Micky van de Ven scored twice as Spurs extended their unbeaten run on the road in the Premier League and handed Everton their first defeat at Hill Dickinson Stadium.
Everton were unbeaten in their last five matches at their recently opened stadium at the dockside location, having left Goodison Park behind after more than a century at the conclusion of last season.
But Tottenham's leader Van de Ven pounced twice from set-pieces in the first half to place their impressive record at risk, and they were failed to mount a comeback before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - headed home a third to put the game to bed.
The Everton defender thought he had equalized the tally five minutes after the defender's opener, glancing a bullet header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, failed to convert a handful of chances, while the Italian goalkeeper made a series of fine saves to guarantee Tottenham went five away games without defeat in the Premier League.
But the video assistant referee stepped in, instructing the match official to review the score on the screen and the official ruled that the winger and the attacker were in offside positions and had interfered with the Spurs keeper.
This victory moves the manager's side into third place in the division, five points off local foes and table-toppers Arsenal.
Everton remain in 14th position and sit half a dozen points clear of the drop zone.
Tottenham analysis: Van de Ven fulfils role at both ends of pitch
Following a drab weekday performance in the European competition against Monaco, where they mustered a only two shots on goal, Frank opted for Randal Kolo Muani up front instead of ex-Everton forward the Brazilian.
The summer signing was unable to influence the game before being substituted for the substitute after an hour on the pitch, but it turns out he wasn't needed in the final outcome.
Defender Van de Ven converted into an attacking force to be feared.
Spurs' first goal came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball toward the six-yard box for an free the defender to head home.
And Ven de Ven - stepping up as captain in Cristian Romero's absence - added his next goal in first-half stoppage time as he outjumped Jordan Pickford to nod in.
The Dutchman was equally outstanding in defence, combining effectively with his defensive colleague as the duo dealt excellently with the numerous deliveries thrown their way by the opposition.
Everton analysis: Everton missing striker's instinct
The club's recent stadium had been a happy hunting ground, but it seems the novelty may have faded somewhat and supporters flocked to the gates after the midfielder's third for Spurs.
The break in Everton's winning streak at home won't be a major worry for the manager, but their striker situation will be.
The forward and Thierno Barry - the Everton's pair of established strikers - had scored just a single goal between them before the weekend's match.
And they were unable to contribute to that miserable tally on a damp and dreary evening on in Liverpool.
Beto's performance was summed up when he chose to overhead kick a golden opportunity from close range, even with having space and time to reposition for a more conventional shot that would have tested the keeper.
Barry, too, was unable to make an impact after replacing Beto in the second half.
It was not for a shortage of opportunity. The majority of the home side's attacks came through Grealish and Ndiaye, who relentlessly delivered threatening crosses into the Spurs penalty area.
Upcoming fixtures for these two sides?
The Toffees: Moyes' men travel to the Stadium of Light in the top flight on early November at 8 PM.
Tottenham: Spurs travel to Newcastle's ground on Wednesday, 29 October for their next round League Cup match against the Magpies.